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S1 : E1Three Hundred Slopes
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A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather. The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.
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